...me and my team of expert...
While this may have been a throwaway gag, it shows that Dipper believes Soos to be an expert. Again, showing that he knows more than you'd think.
My letter poses a salient question.
As can be discerned from the context, salient means important, or very deep and in-depth. Basically, the opposite of Soos' question.
The letter has an infinity symbol
Where else have we seen an infinity symbol? The Mobius chicken strip, as well as one of the secret society symbols.
What did I shave into my head this morning?
Again, this may have been a throwaway gag, but something seems to be up here. Why would Soos shave a baby duck holding a paddleball into his head? He did seem to deduce that the mailbox was all-knowing pretty quickly. Maybe he's been there before...
When is the end of the world? 3012
Blendin Blandin said he came from the year 207̃012, yet the world ended way back in 3012.
The era of human enlightenment shall never come to pass. / cryptogram in journal
In journal 3, on the maze page, it says that the portal will "herald a new era of mankind's understanding of the universe." Is this changed by the Mailbox's statement?